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This syndrome is not with neutropenia and cancer: emphasis on gram-positive and addressed by any of the guidelines buy discount residronate 35 mg line medicine 1700s. Viridans streptococci Limitations and highlights of the evidence order cheap residronate treatment quadriceps strain. There is no good isolated by culture from blood of cancer patients: clinical and evidence regarding the diagnosis or management of engraftment microbiologic analysis of 50 cases buy residronate 35 mg without prescription treatment group. Diagnostic criteria have been proposed, but not externally 6. A basic point is that engraftment syndrome is a diagnosis of bacteremia in patients with cancer and neutropenia: observa- of exclusion. Rubin M, Hathorn JW, Marshall D, Gress J, Steinberg SM, Clinical research on FN over the last 4 decades has generated an Pizzo PA. Gram-positive infections and the use of vancomycin impressive body of evidence that allows strong recommendations in 550 episodes of fever and neutropenia. However, as the course of the neutropenic episode 8. Karp JE, Dick JD, Angelopulos C, Charache P, Green L, et al. Randomized, double-blind, placebo- becomes more difficult. For example, many patients with persistent controlled clinical trial in patients with acute leukemia. Am J fever may already be receiving antifungal agents with activity Med. Cometta A, Kern WV, De Bock R, Paesmans M, Vandenbergh situation? Similar unanswered questions include the best manage- M, et al. Vancomycin versus placebo for treating persistent ment of fever in patients who are receiving levofloxacin prophy- fever in patients with neutropenic cancer receiving piperacillin- laxis, the approach to recrudescent (as opposed to persistent) fever, tazobactam monotherapy. Empirical adult stem cell transplantation and haematological malignancy. Vardakas KZ, Samonis G, Chrysanthopoulou SA, Bliziotis IA, ics in neutropenic afebrile oncology patients: a systematic Falagas ME. Role of glycopeptides as part of initial empirical review of randomised controlled trials. Hughes WT, Armstrong D, Bodey GP, Feld R, Mandell GL, et tients. Gafter-Gvili A, Fraser A, Paul M, Vidal L, Lawrie TA, et al. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, et al. Clinical practice guideline for the use of antimicrobial agents in 30. Robenshtok E, Gafter-Gvili A, Goldberg E, Weinberger M, neutropenic patients with cancer: 2010 update by the Infectious Yeshurun M, et al. Antifungal prophylaxis in cancer patients Diseases Society of America. Management of febrile neutropenia: ESMO Clinical 31. Bucaneve G, Micozzi A, Menichetti F, Martino P, Dionisi MS, Practice Guidelines. Levofloxacin to prevent bacterial infection in patients with 15. Goodman JL, Winston DJ, Greenfield RA, Chandrasekar PH, patients with cancer: 2010 update by the Infectious Diseases Fox B, et al. A controlled trial of fluconazole to prevent fungal Society of America. Baden LR, Bensinger W, Angarone M, Casper C, Dubberke N Engl J Med. Prevention and treatment of cancer-related infections. Slavin MA, Osborne B, Adams R, Levenstein MJ, Schoch HG, J Natl Compr Canc Netw.

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SHORT formoterol have less systemic effects in asthmatic children 6-11 years- old than cumulative high doses of inhaled terbutaline cheap residronate 35 mg visa treatment glaucoma. Kaplan AE buy discount residronate 35mg medicine 93 3109, Stanbrook M order residronate uk medicine in the 1800s, Travers A, Schiebel N, Rowe BH. Non- 5 selective beta agonists versus beta -agonists for acute asthma. Fenoterol by metered dose inhaler and delay of 5 steroid therapy. A multi-clinic double-blind trial of salbutamol in bronchial 3 asthma. Risk versus benefit considerations for the beta(2)-agonists. What is new with the beta -agonists: issues in the2 6 management of asthma. SHORT albuterol aerosol as maintenance therapy for asthma in adolescent and adult patients. SHORT salmeterol in asthmatic patients with 24-hour spirometry and Holter monitoring. Albuterol treatment for 6-POWDER children with asthma: a comparison of inhaled powder and aerosol. Kemp JP, Hill MR, Vaughan LM, Meltzer EO, Welch MJ, Ostrom NK. Clinical trial of metaproterenol aerosol in bronchial asthma. Quick-relief medications for asthma Page 96 of 113 Final Report Update 1 Drug Effectiveness Review Project Citation Exclusion Code Kesten S, Chapman KR, Broder I, et al. SHORT twice daily inhaled formoterol versus four times daily inhaled albuterol in the management of stable asthma. Effects of salmeterol on arterial blood gases in 6-LONG VS. SHORT patients with stable chronic obstructive pulmonary disease: Comparison with albuterol and ipratropium. Fenoterol inhalation powder and aerosol in the treatment of 6-POWDER asthma. Klusova EV, Semenovich NI, Polivanov EG, Pashkova TL. Berotek 1 treatment of bronchial asthma in combination with ischemic heart disease. A comparison of the effects of subcutaneous orciprenaline, 3 salbutamol and terbutaline in asthmatic children. Treatment of severe attacks of asthma in children with 6 nebulized B2 adrenergic agents. Kozlik-Feldmann R, von Berg A, Berdel D, Reinhardt D. SHORT effects of formoterol and salbutamol on bronchial hyperreactivity and beta-adrenoceptor density on lymphocytes in children with bronchial asthma. Kruse M, Rosenkranz B, Dobson C, Ayre G, Horowitz A. SHORT tolerability of high-dose formoterol (Aerolizer) and salbutamol (pMDI) in patients with mild/moderate, persistent asthma. Comparative study of inhaled salbutamol, 6 ipratropium bromide in chronic bronchitis. Comparison of the 5 bronchodilating effects of salbutamol delivered by a novel multiple dose dry powder inhaler or a conventional metered dose inhaler. Evaluation of a patient 5 questionnaire assessing the use of a novel multiple dose dry powder inhaler following a 4 week treatment with salbutamol. Clinical investigation 5 of a 4 week treatment with salbutamol delivered by a multiple dose dry powder inhaler or a conventional metered dose inhaler. Comparison of inhaled 6-POWDER terbutaline administered by either the Turbuhaler dry powder inhaler or a metered-dose inhaler with spacer in preschool children with asthma. Quick-relief medications for asthma Page 97 of 113 Final Report Update 1 Drug Effectiveness Review Project Citation Exclusion Code LaForce C, Prenner BM, Andriano K, Lavecchia C, Yegen U.

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Beta blockers Page 113 of 122 Final Report Update 4 Drug Effectiveness Review Project 323 discount 35 mg residronate mastercard treatment of gout. Parikka H buy residronate 35mg amex medications 512, Toivonen L generic 35mg residronate fast delivery medications going generic in 2016, Heikkila L, Virtanen K, Jarvinen A. Comparison of sotalol and metoprolol in the prevention of atrial fibrillation after coronary artery bypass surgery. Pasta L, Pagliaro L, SImonetti R, Maringhini A, Marceno M, al. Propranolol for prevention of upper GI rebleeding in cirrhosis. Beta blockade to prevent atrial dysrhythmias following coronary bypass surgery. The problems of morbidity and therapy in borderline hypertension. Schweizerische Medizinische Wochenschrift Journal Suisse de Medecine. Penzien DB, Holroyd K, Cordingley G, Wagner M, Jackson B. Propranolol in the treatment of migraine headache: a meta-analytic review of the research literature. Perez V, Puiigdemont D, Gilaberte I, Alvarez E, Artigas F, Grup de Recerca en Trastorns A. Efficacy and safety of atenolol, enalapril, and isradipine in elderly hypertensive women. Effects of beta receptor antagonists on left ventricular function in patients with clinical evidence of heart failure after myocardial infarction. A double-blind comparison of metoprolol and xamoterol. Effects of beta receptor antagonists in patients with clinical evidence of heart failure after myocardial infarction: double blind comparison of metoprolol and xamoterol. Reduction of enzyme levels by propranolol after acute myocardial infarction. A comparison of a hydrochlorothiazide plus triamterene combination (Dyazide) and atenolol in the treatment of patients with mild hypertension: a multicentre study in general practice. Pomier-Layrargues G, Villeneuve JP, Willems B, Huet PM, Marleau D. Systemic and hepatic hemodynamics after variceal hemorrhage: effects of propranolol and placebo. Portegies MCM, Brouwer J, Van de Ven LLM, Viersma JW, Lie KI. Effects of bisoprolol and isosorbide dinitrate on the circadian distribution of myocardial ischemia. Current Therapeutic Research, Clinical & Experimental. Blood pressure and mood responses in hypertensive patients on antihypertensive medications. Journal of the American Academy of Nurse Practitioners. Beta blockers Page 114 of 122 Final Report Update 4 Drug Effectiveness Review Project 339. Poulter NR, Sanderson JE, Thompson AV, Sever PS, Chang CL. Comparison of nifedipine and propranolol as second line agent for hypertension in black Kenyans. Low-dose combination therapy as first-line hypertension treatment for blacks and nonblacks. The Systolic Hypertension in the Elderly Program (SHEP): an intervention trial on isolated systolic hypertension. Clinical & Experimental Hypertension - Part A, Theory & Practice. The influence of atenolol and propafenone on QT interval dispersion in patients 3 months after myocardial infarction.

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Randomized controlled trials of beta blockers for angina Author Year Allowed other Method of outcome Age Other population Country medications/ assessment and timing of Gender characteristics Study Design interventions assessment Ethnicity (diagnosis purchase residronate master card symptoms zithromax, etc) Head-to-head trials Chieffo sl ntg Patient daily record Mean age=56 discount 35 mg residronate free shipping medications similar to abilify. Randomized controlled trials of beta blockers for angina Author Year Number screened/ Country eligible/ Number withdrawn/lost to fu/ Method of adverse Study Design enrolled analyzed Outcomes effects assessment? Randomized controlled trials of beta blockers for angina Author Year Withdrawals due to adverse Country events (% order residronate visa medicine, adverse Study Design Adverse Effects Reported n/enrolled n) Comments Head-to-head trials Chieffo NR NR Comorbid HTN 1986 Italy Fair quality RCT Dorow NR NR 1990 Fair quality RCT Crossover Beta blockers Page 50 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Country Interventions (drug, regimen, Study Design Eligibility criteria Exclusion criteria duration) Frishman Patients with angina pectoris due to ischemic Co-existent valvular heart disease, congestive heart Pindolol (pin) 10-40 mg daily 1979 coronary artery disease as documented by failure, hypertension, bronchial asthma requiring (n=23) United States coronary angiography or previous MI; positive continued treatment with bronchodilators, severe Propranolol (pro) 40-240 mg daily treadmill exercise test showing at least a 1 mm bradycardia, intermittent claudication, and either (n=18) x 8 weeks Fair quality ECG ST segment depression of the ischemic myocardial infarction or a coronary artery bypass within RCT type in association with typical angina pectoris 3 months pain; at least 5 attacks of angina pectoris/2 weeks for three months with no evidence for an accelerated course Beta blockers Page 51 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Allowed other Method of outcome Age Other population Country medications/ assessment and timing of Gender characteristics Study Design interventions assessment Ethnicity (diagnosis, etc) Frishman Nitroglycerin Patient daily record Mean age: 55 Diagnosis of coronary artery disease 1979 Treadmill (protocol nr) 85. Randomized controlled trials of beta blockers for angina Author Year Number screened/ Country eligible/ Number withdrawn/lost to fu/ Method of adverse Study Design enrolled analyzed Outcomes effects assessment? Frishman NR/NR/40 NR/NR/40 analyzed Angina attacks/2 weeks(% reduction):pin=(- NR 1979 41. Randomized controlled trials of beta blockers for angina Author Year Withdrawals due to adverse Country events (%, adverse Study Design Adverse Effects Reported n/enrolled n) Comments Frishman Overall incidence: pin=4/23(17. Randomized controlled trials of beta blockers for angina Author Year Country Interventions (drug, regimen, Study Design Eligibility criteria Exclusion criteria duration) van der Does Male or female (postmenopausal or using Contraindications to study drugs/exercise testing; other Carvedilol (car) 100 mg daily 1999 reliable contraceptive methods) treated or forms of angina pectoris (vasospastic, unstable); (n=247) Europe untreated patients (70% narrowing of a major phlebothrombosis; disorders of impulse coronary vessel) or MI (electrocardiogram or formation/conduction (resting heart rate <45 beats/min, cardiac enzymes), or a previous positive bundle brach block, pacemaker); obstructive airways exercise test with occurrence of angina and ST- disease; insulin-dependent DM; relevant hepatic segment depression; capable of performing impairment; gross obesity; alcohol/drug abuse; epilepsy; upright bicycle ergometric exercise tests; not to concomitant drugs interfering with study objectives (e. Randomized controlled trials of beta blockers for angina Author Year Allowed other Method of outcome Age Other population Country medications/ assessment and timing of Gender characteristics Study Design interventions assessment Ethnicity (diagnosis, etc) van der Does Nitrates Erect bicycle ergometric exercise Mean age: car=62; met=61 %smokers: car=14; met=19 1999 %male: car=72; met=71 %systemic hypertension: car=38; met=33 Europe Race nr %diabetes mellitus: car=15; met=13 %dyslipidemia: car=32; met=31 Fair quality %anterior MI: car=9; met=11 RCT %posterior MI: car=18; met=17 %positive angiography: car=23; met=22 %1-vessel disease: car=13; met=10 %2-vessel disease: car=5; met=8 %3-vessel disease: car=5; met=3 Beta blockers Page 56 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Number screened/ Country eligible/ Number withdrawn/lost to fu/ Method of adverse Study Design enrolled analyzed Outcomes effects assessment? Randomized controlled trials of beta blockers for angina Author Year Allowed other Method of outcome Age Other population Country medications/ assessment and timing of Gender characteristics Study Design interventions assessment Ethnicity (diagnosis, etc) Narahara Sublingual Patient diary used to measure (1) Mean age=61 History of prior MI = 42% 1990 nitroglycerin angina frequency; and (2) 21. Randomized controlled trials of beta blockers for angina Author Year Number screened/ Country eligible/ Number withdrawn/lost to fu/ Method of adverse Study Design enrolled analyzed Outcomes effects assessment? Randomized controlled trials of beta blockers for angina Author Year Withdrawals due to adverse Country events (%, adverse Study Design Adverse Effects Reported n/enrolled n) Comments Narahara Overall side effects (considered to be due to drug NR 1990 therapy): B20=50%; B40=37%; P160=42%; United States P320=45% Fair quality # patients; sample sizes nr Fatigue: B20=1; B40=3; P160=4; P320=3 Increased sweating: B20=0; B40-3; P160=0; P320=0 Headache: B20=2; B40=0; P160=2; P320=0 Parasthesia: B20=0; B40=0; P160=0; P320=0 Diarrhea: B20=2; B40=0; P160=0; P320=0 Dyspepsia: B20=0; B40=2; P160=0; P320=0 Tinnitus: B20=2; B40=0; P160=0; P320=0 Angina: B20=0; B40=0; P16-=2; P320=0 Depression: B20=0; B40=2; P160=0; P320=0 Dyspnea: B20=0; B40=2; P160=0; P320=0 Abnormal vision: B20=0; B40=2; P160=0; P320=0 Beta blockers Page 62 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Country Interventions (drug, regimen, Study Design Eligibility criteria Exclusion criteria duration) Kardas 2007 Ischemic heart disease outpatients CCS class I- Unstable angina pectoris, NYHA class III and IV heart Betaxolol 20 mg once daily II, aged 40-75, beta-blockers-niave, whose failure, heart rate <60/min, II or III degree antrio- metoprolol tartrate metropolol 50 mental state enabled conscious participation in ventricular block, systolic blood pressure below 90 mg twice daily for 8 weeks. Beta blockers Page 63 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Allowed other Method of outcome Age Other population Country medications/ assessment and timing of Gender characteristics Study Design interventions assessment Ethnicity (diagnosis, etc) Kardas 2007 Nitrates MEMS, Medication Event Mean age = 58. Patient diary used to measure (1) weekly number os chest pain episodes; and (2) weekly number of short-acting nitrates doses. Beta blockers Page 64 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Number screened/ Country eligible/ Number withdrawn/lost to fu/ Method of adverse Study Design enrolled analyzed Outcomes effects assessment? Kardas 2007 NR/NR/112 13 withdrawn/ 0 loss to fu/96 analyzed for Betaxolol vs. Analyzed 96 due to a MEMS container lost in 2 cases and failure to Reduction in chest pain epidodes download compliance data from the MEMS. Beta blockers Page 65 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Withdrawals due to adverse Country events (%, adverse Study Design Adverse Effects Reported n/enrolled n) Comments Kardas 2007 10. Randomized controlled trials of beta blockers for angina Author Year Country Interventions (drug, regimen, Study Design Eligibility criteria Exclusion criteria duration) Frishman Patients with documented stable angina pectoris Patients with coexistent valvular heart disease, Labetalol (lab) 200-1600 mg daily 1989 and mild to moderate hypertension congestive heart failure, bronchial asthma, severe Propranolol (pro) 80-640 mg daily United States bradycardia (resting heart rate less than 50 beats/min), x 4 months intermittent claudication, myocardial infarction within 3 Poor quality months, and age above 70 years or under 18 years RCT Beta blockers Page 67 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3. Randomized controlled trials of beta blockers for angina Author Year Allowed other Method of outcome Age Other population Country medications/ assessment and timing of Gender characteristics Study Design interventions assessment Ethnicity (diagnosis, etc) Frishman HCTZ 50 mg daily Treadmill ergometer exercise Center 1 NR 1989 (if standing DBP > tests (Bruce protocol) Mean age: lab=58; pro=57 United States 100 mm Hg) Patient diary Gender (%male): lab=66. Randomized controlled trials of beta blockers for angina Author Year Number screened/ Country eligible/ Number withdrawn/lost to fu/ Method of adverse Study Design enrolled analyzed Outcomes effects assessment? Frishman NR/NR/41 12 withdrawn/1 lost to fu/34 analyzed for Total exercise time (%D in sec) Questioned generally 1989 efficacy Center 1: lab=(+7); pro=(+12) about occurrence of United States Center 2: lab=(+23); pro=(+40) adverse events Time to angina onset(%D in sec) specifically regarding Poor quality Center 1: lab=(+29); pro=(+38) occurrence of dyspnea, RCT Center 2: lab=(+58); pro=(+66) palpitations, sexual Number of patients with angina dysfunction, GI endpoint(D%) disturbances and Center 1: lab=(-67); pro=(-63) dizziness Center 2: lab=(-38); pro=(-50) Beta blockers Page 69 of 494 Final Report Update 4 Drug Effectiveness Review Project Evidence Table 3.

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